13.1.3 - Lead Optimization
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Practice Questions
Test your understanding with targeted questions
Define what a lead compound is.
💡 Hint: Think about its role in the drug discovery process.
What does SAR stand for?
💡 Hint: Consider what this acronym represents in drug development.
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Interactive Quizzes
Quick quizzes to reinforce your learning
What does optimizing a lead compound generally aim to improve?
💡 Hint: Consider the main goals of drug development.
True or False: Potency refers to the amount of drug needed to achieve a specific effect.
💡 Hint: Think about what potency indicates in the context of drug action.
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Challenge Problems
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Given a lead compound with high potency but poor solubility, propose modifications that could enhance its pharmacokinetics while maintaining its therapeutic effect.
💡 Hint: Think about functional groups that are known for enhancing solubility.
You have a drug that is effective but causes significant side effects due to off-target interactions. What strategies can you employ to increase selectivity?
💡 Hint: Reflect on how receptor specificity can be altered.
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