2.4. Applications in Pharmacology

Try these first

1. 1.

   What does KOC stand for?

   Hint

   Think about organic matter.

2. 2.

   Is higher KOW associated with hydrophobic or hydrophilic behaviors?

   Hint

   What happens if a chemical does not like water?

3. 3.

   What does KOC measure?

   • Organic carbon-water partitioning
   • Vapor pressure
   • Solubility

   Hint

   Focus on carbon interactions.

4. 4.

   KOW indicates the preference of a chemical for which phase?

   • True
   • False

   Hint

   Think about lipid vs. aqueous environments.

5. 5.

   If a new pharmaceutical compound has a KOW greater than 10, what might this suggest about its behavior in humans and the environment?

   Hint

   Consider the implications of being lipid-friendly.

6. 6.

   How would you approach the design of a drug that requires effective delivery to brain tissues? Discuss the impact of KOW and hydrophobicity in your reasoning.

   Hint

   Think about how drugs interact with brain tissues.