5.8.3 - Off-target effects
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Practice Questions
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What term describes unintentional gene modification in epigenetic engineering?
💡 Hint: Think about what happens when you aim at a target but hit something else.
Why is specificity important in gene editing?
💡 Hint: Consider what could go wrong if we affect the wrong genes.
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Interactive Quizzes
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What are off-target effects?
💡 Hint: Consider what happens when actions don’t go as planned.
True or False: Off-target effects can only enhance gene expression.
💡 Hint: Think about both sides of gene expression effects.
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Challenge Problems
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Propose an enhanced protocol for using CRISPR-dCas9 to minimize off-target effects for a particular gene therapy application.
💡 Hint: What strategies can improve results based on current research?
Evaluate a scenario where off-target effects led to unintended consequences in a clinical trial. What measures could researchers take to avoid similar future incidents?
💡 Hint: Think broadly about protocols that could enhance care in clinical situations.
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