Genetic Engineering Advance | Epigenetic Engineering and Regulation of Gene Expression by Diljeet Singh | Learn Smarter
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Epigenetic Engineering and Regulation of Gene Expression

Epigenetics encompasses gene expression regulation that occurs independently of DNA sequence alterations. This chapter covers essential mechanisms of epigenetic control, including DNA methylation and histone modifications, alongside advanced tools like CRISPR for targeted editing. It also explores the potential applications in therapies, developmental biology, and the implications of reversibility and heritability of these modifications.

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Sections

  • 5

    Epigenetic Engineering And Regulation Of Gene Expression

    This section covers the concepts of reversibility and heritability in epigenetic changes, highlighting their implications in therapy.

    Learning Practice

  • 5.1

    Description

    Learning

  • 5.2

    Learning Objectives

    This section outlines the learning objectives related to epigenetic engineering and gene expression control.

    Learning Practice

  • 5.3

    Section 1: What Is Epigenetics?

    Learning

  • 5.3.1

    Definition

    Epigenetics refers to heritable changes in gene expression that don't involve changes to the DNA sequence.

    Learning Practice

  • 5.4

    Section 2: Key Epigenetic Mechanisms

    Learning

  • 5.4.1

    Mechanism Effect On Gene Expression

    This section discusses how various epigenetic mechanisms influence gene expression.

    Learning Practice

  • 5.5

    Section 3: Epigenetic Engineering Tools

    Learning

  • 5.5.1

    Crispr-Dcas9 Fusion Proteins

    CRISPR-dCas9 fusion proteins enable targeted epigenetic modifications without altering DNA sequences, offering innovative tools for gene regulation.

    Learning Practice

  • 5.5.2

    Tale And Zinc Finger Fusions

    TALE and Zinc Finger Fusions are important tools for guiding epigenetic enzymes and manipulating gene expression.

    Learning Practice

  • 5.6

    Section 4: Applications Of Epigenetic Engineering

    Learning

  • 5.6.1

    Cancer Therapy

    Cancer therapy focuses on reactivating silenced tumor suppressor genes using epigenetic engineering techniques.

    Learning Practice

  • 5.6.2

    Neurological Disorders

    This section discusses the role of epigenetic engineering in regulating genes linked to neurological disorders.

    Learning Practice

  • 5.6.3

    Developmental Biology

    This section explores epigenetic modifications and their roles in regulating gene expression within developmental biology.

    Learning Practice

  • 5.6.4

    Regenerative Medicine

    Regenerative medicine utilizes epigenetic engineering to reprogram cells to pluripotent states, enhancing therapeutic potential.

    Learning Practice

  • 5.7

    Section 5: Reversibility And Heritability

    Learning

  • 5.8

    Section 6: Challenges And Limitations

    Learning

  • 5.8.1

    Specificity

    This section discusses the significance and challenges of specificity in epigenetic engineering.

    Learning Practice

  • 5.8.2

    Durability

    This section discusses the significance of controlling the durability of epigenetic modifications in therapeutic applications.

    Learning Practice

  • 5.8.3

    Off-Target Effects

    Off-target effects refer to unintended changes in gene expression resulting from epigenetic modifications.

    Learning Practice

  • 5.8.4

    Ethics

    This section discusses the ethical implications associated with epigenetic engineering, particularly in relation to germline editing and the potential long-term consequences of these modifications.

    Learning Practice

  • 5.9

    Chapter Summary

    This chapter discusses the role of epigenetics in gene expression regulation and the tools used for epigenetic modifications without altering DNA sequences.

    Learning Practice

References

Chapter 5_ Epigenetic Engineering and Regulation of Gene Expression.pdf

Class Notes

Memorization

What we have learnt

  • Epigenetics involves herita...
  • Key mechanisms include DNA ...
  • Tools such as CRISPR-dCas9 ...

Final Test

Revision Tests