In this section, we delve into the profound implications of Einstein's mass-energy equivalence relation, E=mc², which states that energy (E) is equal to mass (m) multiplied by the square of the speed of light (c²). This critically redefines the traditional view of mass and energy being conserved separately. Instead, they are interrelated, allowing for mass conversion into other energy forms, such as kinetic energy, especially evident in nuclear reactions. Experimental verifications of this principle highlight its central role in understanding nuclear binding energy and the processes of fission and fusion, which are fundamental to harnessing nuclear energy. Furthermore, the section applies this understanding to calculate the energy equivalent of mass, emphasizing the enormous energy yield from seemingly small masses during nuclear transformations.