The Roman Empire was a vast entity that encompassed diverse cultures and regions across Europe, North Africa, and the Middle East. It was organized under a distinct political regime, where power was centralized with the emperor, supported by the Senate and a professional army. The chapter explores how the empire managed its vast territories, the socioeconomic dynamics at play, and the eventual crises that led to its transformation during late antiquity, culminating in the rise of Islam and the fragmentation of the empire.