Detailed Summary of the Cardiac Cycle
The cardiac cycle is an essential physiological process that refers to the sequence of events involving the contraction (systole) and relaxation (diastole) of the heart's chambers. Each full cycle begins with all four chambers of the heart in a relaxed state, or joint diastole. During this period, blood flows passively from the pulmonary veins and vena cava into the left and right ventricles through open atrioventricular (tricuspid and bicuspid) valves, while the semilunar valves (guarding the pulmonary arteries and aorta) remain closed.
Once the sino-atrial node (SAN) generates an action potential, it initiates atrial contraction (atrial systole), pushing additional blood into the ventricles by about 30%. This electrical impulse spreads to the atrio-ventricular node (AVN) and down the bundle of His, causing the ventricles to contract (ventricular systole). This contraction elevates ventricular pressure, closing the atrioventricular valves to prevent backflow and opening the semilunar valves. Blood is then ejected into the pulmonary artery and aorta.
The ventricles then enter diastole as pressure decreases and the semilunar valves close. The cycle's duration averages 0.8 seconds with each ventricle pumping about 70 mL of blood per cycle (stroke volume). The total blood volume heart pumps in one minute (cardiac output) averages about 5 liters in a healthy adult. This cyclical contraction and relaxation, capable of producing heart sounds 'lub' and 'dub', is regulated by specialized pacemaker cells and can vary with physical activity levels.