The cardiac activity in vertebrates is regulated intrinsically due to specialized muscular structures known as nodal tissue, categorizing the heart as myogenic. The sino-atrial node (SAN) plays a pivotal role in setting the pace of heartbeats, generating 70-75 action potentials per minute, thus regulating heart rhythm. In essence, the heart operates on an intrinsic system that provides it the ability to auto-regulate its activities. However, this intrinsic regulation can be influenced by external factors: the autonomic nervous system (ANS) play a critical role here. Hormones released from the adrenal medulla can enhance cardiac output, while the sympathetic component of the ANS can increase heart rate and the strength of ventricular contractions. Conversely, the parasympathetic division can reduce heart function. This interaction between intrinsic and extrinsic regulation is vital for maintaining optimal cardiac performance under various physiological conditions.