13. Analysis Methods – Gas Chromatography (Mass Spectrometry)
Mass spectrometry is a vital analytical method that allows for the precise examination of organic compounds through ionization and fragmentation. The methodology includes the use of a mass analyzer to separate ions based on their mass-to-charge ratio, enabling a detailed analysis of the components in a sample. This chapter discusses key aspects of gas chromatography coupled with mass spectrometry (GC-MS), including the functionality of mass analyzers, data processing for compound identification, and quantification techniques.
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What we have learnt
- Mass spectrometry involves ionizing compounds and measuring the resulting fragments.
- A mass analyzer, such as a quadrupole, filters ions for analysis based on their mass-to-charge ratio.
- Comparison with library spectra is essential for identifying unknown compounds based on mass spectrometry data.
Key Concepts
- -- Mass Spectrometry (MS)
- An analytical technique used to measure the mass-to-charge ratio of ions, which helps in identifying chemical compounds based on their mass fragments.
- -- Gas Chromatography (GC)
- A method for separating volatile organic compounds in a mixture, often paired with MS for detailed analysis.
- -- Quadrupole Mass Analyzer
- A type of mass analyzer that uses four rods to filter ions based on their mass-to-charge ratio, allowing selective analysis of different ionized fragments.
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