Chemical coordination and integration in the human body is primarily achieved through hormones produced by various endocrine glands, which regulate metabolic processes, growth, and various physiological functions. Hormones act as intercellular messengers, and their effects are mediated through specific receptors on target cells. The chapter discusses the structure, function, and mechanisms of action for major endocrine glands and their hormones, including the hypothalamus, pituitary, thyroid, and adrenal glands, along with their impact on health and disease.